The world is changing, history is changing, and the times are changing. A great transformation unprecedented in a century is profoundly reshaping the international competitive landscape, which in turn is affecting the regional economic layout. Looking back at history, behind every major urban transformation, there are traces of technological progress, industrial upgrading, changes in international relations, and shifts in national strategies, but they are equally closely related to the choices and efforts of the cities themselves. Now, a new round of great changes has arrived. How can the Chinese eastern coastal areas maintain their leading advantages? How can the central and western regions of China ride the tide of the revival of land power and make further progress? Can the Northeast China change their future under the new geopolitical pattern? Can ordinary cities catch up by riding the wave of the new round of technological revolution? How can mega-cities and super-large cities meet the challenges of high-quality development? In the face of great changes, who will advance and who will retreat?