To cultivate healthcare big data talents in a more systematic way and promote the deep integration of big data and the healthcare industry, under the guidance of the National Health Commission of the People’s Republic of China, the School of Clinical Medicine of Tsinghua University compiles this healthcare big data textbook. This textbook is targeted at high-quality talents aspiring to engage in healthcare big data innovation, as well as professionals in the healthcare industry. It systematically sorts out multiple dimensions of healthcare big data in line with the times, aiming to cultivate composite management talents and professional application talents who possess big data thinking and awareness, and have a solid foundation of medical knowledge.